The focus on nanotechnology for improved bioavailability and drug delivery is of increasing\nimportance for control of different human diseases. Therefore, numerous nanoformulations have\nbeen developed for the oral bioavailability of different drugs. This review introduces applications\nof nanomedicine to enhance the biological activities of thymoquinone (TQ) to control different\ndiseases in several in vivo studies as a preliminary investigation for human disease treatment with\nnano-TQ. Nano-TQ effectively augments the anticancer roles of doxorubicin by upregulation of\nP53 and downregulation of Bcl2 and potentiates paclitaxelâ??s apoptosis in MCF-7 breast cancer\ncells. Moreover, nano-TQ protects against diabetes, inflammation, CNS, and hepatotoxicity, mainly\nby enhancement of organsâ?? antioxidant status. We summarize the pros and cons of several FDA\napproved nanoparticle-based therapeutics and discuss the roadblocks in clinical translation, along\nwith potential nano-TQ strategies to overcome these roadblocks. From this review, we can conclude\nthat nano-TQ may be considered as a promising nutraceutical for human health.
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